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ARM TECHNOLOGY 

Addressing the Challenges: ARM’s Solution to Pain Measurement

Our mission is to redefine how pain is understood and measured through innovative technology and scientific excellence
  • Problem : Inefficient

Research with time-intensive training requirements. Delays therapeutic development with inefficient workflows.

  • ARM Solution : Efficiency

Requires only ~1 hour of training, accelerates testing, and reduces habituation time development with inefficient workflows.

  • Problem : Experimenter effects

The presence of different researchers has well documented effects on resulting behavior. Sex-dependent effects are particularly prominent creating difficulties for interpretation.

  • ARM Solution : Remote Operation

Requires only ~1 hour of training, accelerates testing, and reduces habituation time.

  • Problem : Error and Bias

Relies on subjective manual scoring, introducing human error. Inconsistent application across users and studies. Lacks objective biomarkers for reliable pain measurement. Generates unreliable data due to methodological variability.

  • ARM Solution : Increased Accuracy

Provides 15x more accurate targeting than manual methods and removes variability in stimulus duration.

  • Problem: Focus on the Hind Paw

Pain effects the whole body but most studies focus on the mouse hindpay, due to experimental challenges.

  • ARM Solution: Expanded Targeting

Allows precise targeting of the feet, heel, stomach, and pubic region.

  • Problem : Limited Analysis Options

Current tools often rely on subjective scoring, often differing between users and studies. In Evoked tests data is often limited to only stimulus sensitivity and not pain state.

  • ARM Solution : New Analysis Options

Enables automated force threshold measurement, withdrawal latency, and high-speed (500 fps) analysis.

  • Problem : High Barrier to Use

Many systems require months of specialized training to apply correctly. Some researchers cannot perform these tests based on physical limitations

  • ARM Solution : Automation of Stimulus Delivery

Simplifies operation and reduces need for specialized training.

  • Stimulus Delivery

Equipped with force-sensor touch and pinprick stimulus; can apply a consistent force, a force ramp, or a poke upon contact.

  • Add-Ons

Options available for optogenetic and brush stimuli; hot and cold stimulus add-ons are in development.

  • Data Integration

Supports integration of stimulus, behavioral, and brain imaging data.

  • Compact Design

Fits within a 75 × 45 × 50 cm cube, accommodating up to 5 mice simultaneously. Options for 10 mice or 5 rats are also available.

  • Control & Operation

Stimulus delivery and data capture are managed via the ARM app and a bottom-up aiming camera (included). Operated through Windows desktop with controller and keyboard support.

  • Data Recording

Utilizes three cameras recording at 500 fps, alongside a force-measuring stimulus option.

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